Prostaglandin periostitis
Show titles
Hide titles
Overview
Case 1
Prostaglandin periostitis
Case 2
Prostaglandin periostitis
Case 3
Prostaglandin periostitis
Case 4
Prostaglandin periostitis
Prostaglandin periostitis
Overview
History: 27-day-old female with a congenital heart defect (DORV, VSD)
Findings
Diffuse periosteal bone formation.
Differential
- Prostaglandin periostitis
- Physiologic periostitis
- Trauma
- Caffey's disease
- Congenital syphilis
- Hypervitaminosis A
- Scurvy
- Hypertrophic osteoarthropathy
- Leukemia
- Skeletal metastasis
Impression
Prostaglandin periostitis
Discussion
- Prostaglandin E1 is commonly used to maintain a patent ductus arteriosus in patients with ductus-dependent congenital heart disease.
- Periosteal bone formation is usually seen with long-term prostaglandin treatment (>40 days), but can be seen with short-term therapy with prostaglandin E2 (9-14 days).
- Symmetrical distribution is not always present.
- Generally self-limited with no effect on subsequent bone growth and development.
- Complete resolution common in 6 months to 1 year.
History: 25 day old male with Tetralogy of Fallot
Findings
Cardiomegaly and boot-shaped heart consistent with the provided history of Tetralogy of Fallot
Differential
- Prostaglandin periostitis
- Physiologic periostitis
- Trauma
- Caffey's disease
- Congenital syphilis
- Hypervitaminosis A
- Scurvy
- Hypertrophic osteoarthropathy
- Leukemia
- Skeletal metastasis
Impression
Prostaglandin periostitis
Discussion
- Prostaglandin E1 is commonly used to maintain a patent ductus arteriosus in patients with ductus-dependent congenital heart disease (such as TOF in this case).
- Periosteal bone formation is usually seen with long-term prostaglandin treatment (>40 days), but can be seen with short-term therapy with prostaglandin E2 (9-14 days).
- Symmetrical distribution is not always present.
- Generally self-limited with no effect on subsequent bone growth and development.
- Complete resolution common in 6 months to 1 year.
History: 3-month-old female with a ventricular septal defect
Findings
Differential
- Prostaglandin periostitis
- Physiologic periostitis
- Trauma
- Caffey's disease
- Congenital syphilis
- Hypervitaminosis A
- Scurvy
- Hypertrophic osteoarthropathy
- Leukemia
- Skeletal metastasis
Impression
Prostaglandin periostitis
Discussion
- Prostaglandin E1 is commonly used to maintain a patent ductus arteriosus in patients with ductus-dependent congenital heart disease.
- Periosteal bone formation is usually seen with long-term prostaglandin treatment (>40 days), but can be seen with short-term therapy with prostaglandin E2 (9-14 days).
- Symmetrical distribution is not always present (as in this case)
- Generally self-limited with no effect on subsequent bone growth and development.
- Complete resolution common in 6 months to 1 year.
History: 2 month old male with Tetralogy of Fallot
Findings
Differential
- Prostaglandin periostitis
- Physiologic periostitis
- Trauma
- Caffey's disease
- Congenital syphilis
- Hypervitaminosis A
- Scurvy
- Hypertrophic osteoarthropathy
- Leukemia
- Skeletal metastasis
Impression
Prostaglandin periostitis
Discussion
- Prostaglandin E1 is commonly used to maintain a patent ductus arteriosus in patients with ductus-dependent congenital heart disease (such as TOF in this case)
- Periosteal bone formation is usually seen with long-term prostaglandin treatment (>40 days), but can be seen with short-term therapy with prostaglandin E2 (9-14 days)
- Symmetrical distribution is not always present.
- Generally self-limited with no effect on subsequent bone growth and development.
- Complete resolution common in 6 months to 1 year
