Prostaglandin Periostitis

Prostaglandin Periostitis:

• Occurs as a side effect of treatment with prostaglandins, particularly prostaglandin E1 and E2.
• Periosteal bone formation is typically seen with long-term prostaglandin treatment (>40 days) but can also occur with short-term therapy with prostaglandin E2 (9-14 days).
• Symmetrical distribution is not always present.
• Generally self-limited with no effect on subsequent bone growth and development.
• Complete resolution is common within 6 months to 1 year.

Radiographic findings:

Differential diagnosis:

• Physiologic periostitis
• Trauma
• Caffey's disease
• Congenital syphilis
• Hypervitaminosis A
• Scurvy
• Hypertrophic osteoarthropathy
• Leukemia
• Skeletal metastasis